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TIRZEPATIDE Q&A

Q. What is Tirzepatide?

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  • Tirzepatide is a medication that is gaining attention for its dual action in treating type 2 diabetes and promoting weight loss. It is a dual agonist, meaning it activates two different types of receptors in the body:

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  • GLP-1 Receptor: Like semaglutide, tirzepatide activates the GLP-1 receptor, which helps increase insulin production, reduce glucagon secretion, slow gastric emptying, and suppress appetite.

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  • GIP Receptor (Glucose-dependent Insulinotropic Polypeptide): Tirzepatide also activates the GIP receptor, which further enhances insulin secretion and has additional effects on appetite regulation and metabolism.

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  • This dual mechanism makes tirzepatide potentially more effective than medications that target only the GLP-1 receptor. Clinical trials have shown that tirzepatide can lead to significant reductions in blood sugar levels and substantial weight loss, making it a promising option for people with type 2 diabetes and those looking to manage their weight.

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Q. How does it work?

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  • Tirzepatide works by activating two types of receptors in your body:

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  • GLP-1 Receptor: This helps increase insulin production, reduce glucagon release, slow down stomach emptying, and reduce appetite, helping with blood sugar control and weight loss.

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  • GIP Receptor: This further boost insulin production and helps regulate appetite and metabolism.

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  • By targeting both receptors, tirzepatide provides more comprehensive effects in managing blood sugar levels and promoting weight loss than medications targeting only the GLP-1 receptor.

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Q. What is the difference between Semaglutide and Tirzepatide?

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  • The key difference between semaglutide and tirzepatide is in their mechanisms:

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  • Semaglutide targets only the GLP-1 receptor, helping to control blood sugar and reduce appetite.

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  • Tirzepatide targets both the GLP-1 and GIP receptors, which may enhance its effects on blood sugar control and weight loss.

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  • Because tirzepatide acts on two receptors, it might lead to greater weight loss and improved blood sugar control compared to semaglutide.

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​Q. How often do you inject?

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Injections of Tirzepatide are typically administered once a week. However, if you experience side effects like nausea or feel sick after the injection, a healthcare provider may consider adjusting the dosing schedule. This could involve split dosing, where the weekly dose is divided into two smaller injections given twice a week to help minimize the severity of side effects.

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Q. How quickly will you see results?

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Most patients begin to see results within the first two weeks of starting semaglutide, though for some, it may take up to a month or longer to notice significant changes. Everyone's body responds differently, so the timeline for seeing results can vary from person to person. Consistency with the treatment and following any additional lifestyle recommendations your healthcare provider provides can also influence how quickly you see results.

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Q. How should I store it?

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Semaglutide should be stored in the refrigerator to maintain its effectiveness. Keep it at a temperature between 36°F to 46°F (2°C to 8°C). Avoid freezing the medication; if it does freeze, do not use it. Additionally, ensure that the vial is stored in its original packaging until you can use it. If you have any concerns about storage, consult your healthcare provider.

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Q. I missed my dose. What should I do?

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If you miss a dose of Tirzepatide, take it as soon as you remember. After taking the missed dose, adjust your schedule so that your next injection is one week from the day you took the missed dose. Continue with this new schedule going forward. If you are close to your next scheduled dose (less than 2 days), skip the missed dose and take the next one as initially planned. Always follow your healthcare provider's guidance for dosing adjustment.

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Q. I am nauseous; what do I do?

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If you're experiencing nausea after your Tirzepatide injection, let your healthcare provider know. Nausea is a common side effect, and it often subsides over time. Here are some strategies to manage it:
 

  • Take your injection at night before bed: This can help you sleep through most of the nausea.

  • Eat smaller, more frequent meals: Avoid large or heavy meals, as they can worsen nausea and cause gas.

  • Consider prescription medications: Your provider may prescribe medications to help offset the nausea.

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If the nausea persists or worsens, consult your healthcare provider for further guidance.

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Q. I am constipated; how can I fix that?

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If you are experiencing constipation, taking Metabolic Refresh daily can help keep you regular. In addition to this supplement, you might also consider the following tips:
 

  • Increase fiber intake: Eating more fruits, vegetables, and whole grains can help prevent constipation.

 

  • Stay hydrated: Drinking plenty of water throughout the day is important for maintaining healthy digestion.

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  • Regular physical activity: Exercise can help stimulate bowel movements.

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If constipation persists despite these measures, consult your healthcare provider for further advice.

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